Relive the Paralympics’ Most Inspiring Moment of the Year






Back in July, we covered how social media would be critical to the success of the 2012 Paralympic Games. The Paralympics ended in September, but the International Paralympic Committee is still using the web to shine a light on unheralded athletes and tell stories of remarkable inspiration.


[More from Mashable: Watch the Scariest Skiing Lesson of All Time]






The committee revealed its top moment of 2012 in a video posted to YouTube on Sunday. It profiles Italian cyclist Alex Zanardi winning gold in London after losing his legs in an auto racing accident in 2001. The image of a triumphant Zanardi lifting his hand-cycling tricycle above his head with one arm post-race is nothing short of astounding.


[More from Mashable: NBA Star’s Kick to the Groin Sparks Online Debate]


For a longer look at Zanardi’s amazing achievement and to relive one of 2012′s sweetest sports moments, watch the full video above.


BONUS: 2012′s best sports social media moments


1. Devin McCourty Tweets While Playing in the Super Bowl (Sort of)


As New England Patriot Devin McCourty took on the New York Giants in Super Bowl XLVI, his followers were still able to receive real-time updates from his social feeds. But he wasn’t sneaking tweets between plays or during timeouts. Devin and twin brother Jason, who plays for the Tennessee Titans, share their Twitter and Facebook accounts. The Super Bowl showcased one of the more creative approaches to social media in the sports world.


Image courtesy of Devin and Jason McCourty’s Instagram.


Click here to view this gallery.


Thumbnail image credit Getty Images/AFP/Leon Neal


This story originally published on Mashable here.


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Pasadena's Rose Parade kicks off on a cold morning


PASADENA, Calif. (AP) — The 124th Rose Parade in Pasadena kicked off on a chilly New Year's morning with the theme "Oh the Places You'll Go!" named in honor of the Dr. Seuss book.


Led by this year's grand marshal, British primatologist Jane Goodall, the parade features 42 floats covered with flowers and plant material, 23 marching bands and 21 equestrian units from across the country.


An estimated 700,000 spectators are lining the streets to view the 5-mile-long spectacle, which is broadcast around the world. This year's parade features the first-ever float entered by the Defense Department and a couple getting married on a float.


The $247,000 military float is a replica of the Korean War Veterans Memorial in Washington to commemorate the veterans from that conflict.


The float that scooped up the parade's grand "Sweepstakes" prize for the most beautiful floral presentation and design was "Dreaming in Paradise" by fruit and vegetable producer Dole.


Die-hard parade fans staked out their spots early Monday with folding chairs, hammocks and portable barbeque grills.


They brought in the new year by throwing marshmallows, shaving cream and tortillas, and then hunkered down to stay warm in sleeping bags during a particularly cold night for Southern California.


The wave of under-40-degree temperature spurred a number of cold-weather exposure calls to emergency personnel, police department spokeswoman Lisa Derderian told City News Service.


As of 8 a.m. Tuesday, police had made a total of 22 arrests along the parade route since 6 p.m. Monday, said police Lt. Rick Aversan.


All but one arrest were for public intoxication. The other was for possession of burglary tools that could have been used to break into cars, police said.


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Clinton receiving blood thinners to dissolve clot


WASHINGTON (AP) — Doctors treating Secretary of State Hillary Rodham Clinton for a blood clot in her head said blood thinners are being used to dissolve the clot and they are confident she will make a full recovery.


Clinton didn't suffer a stroke or neurological damage from the clot that formed after she suffered a concussion during a fainting spell at her home in early December, doctors said in a statement Monday.


Clinton, 65, was admitted to New York-Presbyterian Hospital on Sunday when the clot turned up on a follow-up exam on the concussion, Clinton spokesman Phillipe Reines said.


The clot is located in the vein in the space between the brain and the skull behind the right ear. She will be released once the medication dose for the blood thinners has been established, the doctors said.


In their statement, Dr. Lisa Bardack of the Mount Kisco Medical Group and Dr. Gigi El-Bayoumi of George Washington University said Clinton was making excellent progress and was in good spirits.


Clinton's complication "certainly isn't the most common thing to happen after a concussion" and is one of the few types of blood clots in the skull or head that are treated with blood thinners, said Dr. Larry Goldstein, a neurologist who is director of Duke University's stroke center. He is not involved in Clinton's care.


The area where Clinton's clot developed is "a drainage channel, the equivalent of a big vein inside the skull. It's how the blood gets back to the heart," Goldstein said.


Blood thinners usually are enough to treat the clot and it should have no long-term consequences if her doctors are saying she has suffered no neurological damage from it, Goldstein said.


Clinton returned to the U.S. from a trip to Europe, then fell ill with a stomach virus in early December that left her severely dehydrated and forced her to cancel a trip to North Africa and the Middle East. Until then, she had canceled only two scheduled overseas trips, one to Europe after breaking her elbow in June 2009 and one to Asia after the February 2010 earthquake in Haiti.


Her condition worsened when she fainted, fell and suffered a concussion while at home alone in mid-December as she recovered from the virus. It was announced Dec. 13.


This isn't the first time Clinton has suffered a blood clot. In 1998, midway through her husband's second term as president, Clinton was in New York fundraising for the midterm elections when a swollen right foot led her doctor to diagnose a clot in her knee requiring immediate treatment.


Clinton had planned to step down as secretary of state at the beginning of President Barack Obama's second term. Whether she will return to work before she resigns remained a question.


Democrats are privately if not publicly speculating: How might her illness affect a decision about running for president in 2016?


After decades in politics, Clinton says she plans to spend the next year resting. She has long insisted she had no intention of mounting a second campaign for the White House four years from now. But the door is not entirely closed, and she would almost certainly emerge as the Democrat to beat if she decided to give in to calls by Democratic fans and run again.


Her age — and thereby health — would probably be a factor under consideration, given that Clinton would be 69 when sworn in, if she were elected in 2016. That might become even more of an issue in the early jockeying for 2016 if what started as a bad stomach bug becomes a prolonged, public bout with more serious infirmity.


Not that Democrats are willing to talk openly about the political implications of a long illness, choosing to keep any discussions about her condition behind closed doors. Publicly, Democrats reject the notion that a blood clot could hinder her political prospects.


"Some of those concerns could be borderline sexist," said Basil Smikle, a Democratic strategist who worked for Clinton when she was a senator. "Dick Cheney had significant heart problems when he was vice president, and people joked about it. He took the time he needed to get better, and it wasn't a problem."


It isn't uncommon for presidential candidates' health — and age — to be an issue. Both in 2000 and 2008, Sen. John McCain, R-Ariz., had to rebut concerns he was too old to be commander in chief or that his skin cancer could resurface.


Two decades after Clinton became the first lady, signs of her popularity — and her political strength — are ubiquitous.


Obama had barely declared victory in November when Democrats started zealously plugging Clinton as their strongest White House contender four years from now, should she choose to take that leap.


"Wouldn't that be exciting?" House Democratic leader Nancy Pelosi declared in December. "I hope she goes. Why wouldn't she?"


Even Republicans concede that were she to run, Clinton would be a force to be reckoned with.


"Trying to win that will be truly the Super Bowl," Newt Gingrich, the former House Speaker and 2012 GOP presidential candidate, said in December. "The Republican Party today is incapable of competing at that level."


Americans admire Clinton more than any other woman in the world, according to a Gallup poll released Monday — the 17th time in 20 years that Clinton has claimed that title. And a recent ABC News/Washington Post poll found that 57 percent of Americans would support Clinton as a candidate for president in 2016, with just 37 percent opposed. Websites have already cropped up hawking "Clinton 2016" mugs and tote bags.


Beyond talk of future politics, Clinton's three-week absence from the State Department has raised eyebrows among some conservative commentators who questioned the seriousness of her ailment after she canceled planned Dec. 20 testimony before Congress on the deadly attack on the U.S. diplomatic mission in Benghazi, Libya.


Clinton had been due to discuss with lawmakers a scathing report she had commissioned on the attack. It found serious failures of leadership and management in two State Department bureaus were to blame for insufficient security at the facility. Clinton took responsibility for the incident before the report was released, but she was not blamed. Four officials cited in the report have either resigned or been reassigned.


___


Associated Press writer Ken Thomas in Washington and AP Chief Medical Writer Marilynn Marchione in Milwaukee contributed to this report.


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Senate passes 'cliff' deal, House up next


With 2013 just over two hours old, the Senate voted 89-8 on Tuesday to
approve a last-minute deal to avert income tax hikes on all but the
richest Americans and stall painful spending cuts as part of a
hard-fought compromise to avoid the economically toxic “fiscal cliff.”


The country had already technically tumbled over the cliff by the time the gavel came down on the vote at 2:07 a.m.. The House of Representatives was not due to return to work to take up the measure until midday on Tuesday. But with financial markets closed for New Year's Day, quick action by lawmakers would likely limit the economic damage.


The lopsided margin belied anxiety on both sides about the deal, which emerged from barely two days of talks between Vice President Joe Biden and Republican Senate Minority Leader Mitch McConnell. Among the “no” votes: Republican Senator Marco Rubio, widely thought to have his eye on the 2016 presidential race.


In remarks just before the vote, McConnell repeatedly called the agreement “imperfect” but said it beat allowing income tax rates rise across the board.


“I know I can speak for my entire conference when I say we don’t think taxes should be going up on anyone, but we all knew that if we did nothing they’d be going up on everyone today,” he said. “We weren’t going to let that happen.”


“Our most important priority was to protect middle-class families. This legislation does that,” Democratic Senate Majority Leader Harry Reid said. But Reid cautioned that “passing this agreement does not mean negotiations halt. Far from it.”


Compromises on tax rates

Under the compromise arrangement, taxes would rise on income above $400,000 for individuals and $450,000 for households, while exemptions and deductions the wealthiest Americans use to reduce their tax bill would face new limits. The accord would also raise the taxes paid on large inheritances from 35% to 40% for estates over $5 million. And it would extend by one year unemployment benefits for some two million Americans. It would also prevent cuts in payments to doctors who treat Medicare patients and spare tens of millions of Americans who otherwise would have been hit with the Alternative Minimum Tax.

The middle class will still see its taxes go up: The final deal did not include an extension of the payroll tax holiday. And the overall package will deepen the deficit by hundreds of billions of dollars by extending the overwhelming majority of the Bush tax cuts. Many Democrats had opposed those measures in 2001 and 2003. Obama agreed to extend them in 2010.


Efforts to modify the first installment of $1.2 trillion in cuts to domestic and defense programs over 10 years -- the other portion of the “fiscal cliff,” known as sequestration -- had proved a sticking point late in the game. Democrats had sought a year-long freeze but ultimately caved to Republican pressure and signed on to just a two-month delay while broader deficit-reduction talks continue.


Debt-limit battle looms


That would put the next major battle over spending cuts right around the time that the White House and its Republican foes are battling it out over whether to raise the country's debt limit. Republicans have vowed to push for more spending cuts, equivalent to the amount of new borrowing. Obama has vowed not to negotiate as he did in 2011, when a bruising fight threatened the first-ever default on America's obligations and resulted in the first-ever downgrade of the country's credit rating. Biden sent that message to Democrats in Congress, two senators said.


Experts had warned that the fiscal cliff's tax increases and spending cuts, taken together, could plunge the still-fragile economy into a new recession.


Biden, evidently in good spirits after playing a central role in crafting the deal, said little on his way into or out of a roughly one hour and 45 minute meeting behind closed doors with Senate Democrats. "Happy New Year," he said on the way in. Asked on the way out what his chief selling point had been, the vice president reportedly replied: "Me."


Biden's intervention; hurdles in the House


Hours earlier, a Democratic Senate aide told Yahoo News that "the White House and Republicans have a deal," while a source familiar with the negotiations said President Barack Obama had discussed the compromise with Reid and Democratic House Minority Leader Nancy Pelosi and "they both signed off."


But the House’s Republican leaders, including Speaker John Boehner, hinted in an unusual joint statement that they might amend anything that clears the Senate – a step that could kill the deal.

“Decisions about whether the House will seek to accept or promptly amend the measure will not be made until House members -- and the American people -- have been able to review the legislation,” they said.

Biden, a 36-year Senate veteran, worked out the agreement with McConnell after talks between Obama and Boehner collapsed and a similar effort between McConnell and Reid followed suit shortly thereafter. With the deal mostly done, Obama made a final push at the White House.


“Today, it appears that an agreement to prevent this New Year's tax hike is within sight, but it's not done,” Obama said in hastily announced midday remarks at the White House. “There are still issues left to resolve, but we're hopeful that Congress can get it done – but it’s not done.”


"One thing we can count on with respect to this Congress is that if there is even one second left before you have to do what you’re supposed to do, they will use that last second," he said.


Obama’s remarks – by turns scolding, triumphant, and mocking of Congress – came after talks between McConnell and Biden appeared to seal the breakthrough deal.


“I can report that we’ve reached an agreement on all of the tax issues,” McConnell said on the Senate floor moments later. “We are very, very close to an agreement.”


The Kentucky Republican later briefed Republicans on the details of the deal. Lawmakers emerged from that closed-door session offered hopeful appraisals that, after clearing a few last-minute hurdles, they could vote on New Year’s Eve or with 2013 just hours old.


“Tonight, I hope,” Republican Senator Bob Corker of Tennessee told reporters. “It may be at 1, 2, 3, 4 in the morning. Oh, I guess that’s technically tomorrow.”


Reckoning with the 'sequester'


Republican Senators said negotiators were still working on a way to forestall two months of the “sequester” spending cuts, about $20 billion worth. And some expressed disquiet that the tentative compromise ran high on tax increases and low on spending cuts -- while warning that failure to act, triggering some $600 billion in income tax increases on all Americans who pay it and draconian spending cuts, was the worse option.


McConnell earlier had called for a vote on the tax component of the deal.

“Let me be clear: We’ll continue to work on finding smarter ways to cut spending, but let’s not let that hold up protecting Americans from the tax hike,” McConnell urged. “Let’s pass the tax relief portion now. Let’s take what’s been agreed to and get moving.”

House passage was not a sure thing: Both the AFL-CIO labor union and the conservative Heritage Action organization argued against the package.


The breakthrough came after McConnell announced Sunday that he had started to negotiate with Biden in a bid to "jump-start" stalled talks to avoid the fiscal cliff.


Under their tentative deal, the top tax rate on household income above $450,000 would rise from 35 percent to 39.6 percent -- where it was under Bill Clinton, before the reductions enacted under George W. Bush in 2001 and 2003.


Some congressional liberals had expressed objections to extending tax cuts above the $250,000 income threshold Obama cited throughout the 2012 campaign. Democrats were huddling in private as well to work out whether they could support the arrangement.


Obama responds to critics


Possibly with balking progressives in mind, Obama trumpeted victories dear to the left of his party. "The potential agreement that’s being talked about would not only make sure the taxes don’t go up on middle-class families, it also would extend tax credits for families with children. It would extend our tuition tax credit that’s helped millions of families pay for college. It would extend tax credits for clean energy companies that are creating jobs and reducing our dependence on foreign oil. It would extend unemployment insurance to 2 million Americans who are out there still actively looking for a job."


Obama said he had hoped for "a larger agreement, a bigger deal, a grand bargain," to stem the tide of red ink swamping the country’s finances – but shelved that goal.


"With this Congress, that was obviously a little too much to hope for at this time," he said. "It may be we can do it in stages. We’re going to solve this problem instead in several steps."


The president also looked ahead to his next budgetary battle with Republicans, warning that “any future deficit agreement” will have to couple spending cuts with tax increases. He expressed a willingness to reduce spending on popular programs like Medicare, but said entitlement reform would have to go hand in hand with new tax revenues.


“If Republicans think that I will finish the job of deficit reduction through spending cuts alone … then they’ve another thing coming,” Obama said defiantly. “That’s not how it’s going to work.”


“If we’re serious about deficit reduction and debt reduction, then it’s going to have to be a matter of shared sacrifice. At least as long as I’m president. And I’m going to be president for the next four years, I hope,” he said.

The other “no” votes were: Michael Bennet (D-Col.), Tom Carper (D-Del.), Chuck Grassley (R-Iowa), Tom Harkin (D-Iowa), Mike Lee (R-Utah), Rand Paul (R-Ken.), and Richard Shelby (R-Ala.). Republicans Jim DeMint of South Carolina and Mark Kirk of Illinois as well as Democrat Frank Lautenberg of New Jersey did not vote.
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Myanmar fetes 2013 with first public countdown


YANGON, Myanmar (AP) — Myanmar is ringing in 2013 with its first public New Year's Eve countdown and a grand fireworks display, a celebration unprecedented in the former military-ruled country.


The party is the latest, and perhaps most exuberant, example of the country's emergence from decades of isolation.


Organizers announced that two hours ahead of midnight, about 72,000 people had gathered at the countdown venue, a large field in Yangon, for a chance to do what much of the world does every Dec. 31.


Hundreds of people danced and swayed to musical performances on a huge colorfully lit stage, while other revelers — both young and old — sat on mats they brought with them or perused food stalls as fireworks burst above.


"This is very exciting and also our first experience in celebrating the New Year at a big countdown gathering. We feel like we are in a different world," said Yu Thawda, a university student who came with three of her friends.


Against a backdrop of the city's famed Shwedagon Pagoda, a large screen was to show live New Year's Eve countdowns in Singapore, Malaysia, Indonesia and Thailand leading up to a 60-second countdown to 2013 in Myanmar.


Singers, celebrities, light shows and other festivities were part of the public party, which would have been unthinkable under the former military regime, which banned public gatherings, with the recent exception of the traditional Myanmar New Year in April.


Until this year, New Year's Eve was celebrated privately or inside hotels, but there was no open celebration. Under the military regime the only grand fireworks display was in honor of Armed Forces Day, an annual celebration of military might.


The reformist government that took office last year urged the public to go out and have fun.


"This event is a very good outlet, particularly for young people," said presidential adviser Ko Ko Hlaing, adding that celebrations like this can "help build mutual understanding between the people and the government."


President Thein Sein has freed hundreds of political prisoners, abolished direct media censorship and allowed public protests as part of a democratic transition that has surprised the outside world.


Many in Myanmar, however, remain skeptical. While people in big cities say they live more freely, they also say the reforms have not improved their livelihoods. People in rural areas of grinding poverty cite continuing human rights issues, abuse of power and abysmal health care.


"People are feeling insecure psychologically, but a public celebration will make people feel light and happy and ease the tension," Ko Ko Hlaing said.


Organizers billed the event as "the first time Myanmar celebrates with the world."


The celebration was arranged by local Forever Media group and Index Creative Village, a Thai event organizer.


"We want residents of Yangon to enjoy the public countdown like in other countries," said Win Thura Hlaing, a spokesman for Forever Media group.


___


Associated Press writer Yadana Htun contributed to this report.


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Can Samsung survive without Android?






Samsung (005930) is the world’s top Android smartphone vendor by a staggering margin. Aside from LG (066570), which managed a small $ 20 million profit from its mobile division last quarter, no other global Android vendor can figure out how to make money selling Android phones. Meanwhile, Samsung posted a $ 6 billion profit on $ 47.6 billion in sales in the third quarter, thanks largely to record smartphone shipments and a massive marketing budget. Even as industry watchers turn sour on Apple, Samsung is seen steamrolling into 2013 and its stock is up nearly 50% on the year while Apple (AAPL) shares continue to fall from a record high hit in September. As unstoppable as Samsung appears right now, one key question remains: Is Samsung driving Android’s success or is Android driving Samsung’s success? Starting in 2013, we may finally begin to find out.


[More from BGR: Unreleased ‘BlackBerry X10′ QWERTY phone appears again in new photos]






Earlier this year, BGR wrote about Samsung’s effort to look beyond Android. Even with its own UI and application suite — and even with its own content services — Samsung will always rely on Google (GOOG) if it continues to base its devices on Google’s latest Android builds.


[More from BGR: RIM teases BlackBerry 10 launch with image of first BB10 smartphone]


This isn’t necessarily a bad thing, but it means Samsung will never truly control the end-to-end experience on its products. It also means Samsung will never truly own its smartphones and tablets. Instead, Samsung’s devices will deliver an experience that is an amalgamation of Google’s vision and its own.


But there are alternative options. One example is the path Amazon (AMZN) has taken. Amazon let Google do the grunt work and then took its open-source Android OS and built its own software and service layer on top. Kindle Fire users don’t sit around waiting for Android updates — many of them don’t even know they’re using an Android-powered tablet.


Samsung could do the same thing, but there is a great deal of prep work that would need to be done first. Amazon’s efforts were so successful (depending on your measure of success) because the company already had a massive ecosystem in place before it even launched its first device. Streaming movies and TV shows, eBooks, retail shopping and a stocked application store were all available on the Kindle Fire from day one.


Samsung doesn’t have this luxury. Yet.


Samsung could also take ownership of a new OS, and Tizen may or may not end up being that OS. Samsung is co-developing the new Linux-based mobile platform with Intel (INTC) and others, and a new rumor from Japan’s The Daily Yomiuri suggests Samsung plans to launch its first Tizen phone in 2013. “Samsung will probably begin selling the [Tizen] smartphones next year and they are likely to be released in Japan and other countries at around the same time,” the site’s sources claim.


This will be a slow process. If Samsung follows the same path it took with Bada, Samsung’s earlier Linux-based OS that was folded into the Tizen project, things will start out slow as Samsung launches regional devices that are restricted to a few Eastern markets. Testing the waters before dumping serious marketing dollars into the project isn’t a bad idea, especially considering the battle at the bottom of the smartphone OS food chain that will already be taking place in 2013.


But one thing is clear: Samsung is looking to broaden its strategy and move beyond a point where it relies entirely on another company for its smartphone software.


This article was originally published by BGR


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Kanye West, Kim Kardashian expecting 1st child


ATLANTIC CITY, N.J. (AP) — A kid for Kimye: Kanye West and Kim Kardashian are expecting their first child.


The rapper announced at a concert Sunday night that his girlfriend is pregnant. Kardashian was in the crowd at Revel Resort's Ovation Hall with her mother, Kris Jenner, and West's mentor and best friend, Jay-Z. West told the crowd of more than 5,000 in song form: "Now you having my baby."


The crowd roared. And so did people on the Internet.


The news instantly went viral on Twitter and Facebook, with thousands posting and commenting on the expecting couple.


Most of the Kardashian clan also tweeted about the news, including Kim's sisters. Kourtney Kardashian wrote: "Another angel to welcome to our family. Overwhelmed with excitement!"


West, 35, also told concertgoers to congratulate his "baby mom" and that this was the "most amazing thing."


Representatives for West and Kardashian, 32, didn't immediately respond to emails about the pregnancy.


The rapper and reality TV star went public in March.


Kardashian married NBA player Kris Humphries in August 2011 and their divorce is not finalized.


West's Sunday-night show was his third consecutive performance at Revel. He took the stage for nearly two hours, performing hits like "Good Life," ''Jesus Walks" and "Clique" in an all-white ensemble with two bandmates.


___


AP Writer Bianca Roach contributed to this report.


___


Follow Mesfin Fekadu on Twitter at http://twitter.com/MusicMesfin . Follow Bianca Roach at http://twitter.com/B__Roach


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FDA approves 1st new tuberculosis drug in 40 years


WASHINGTON (AP) — The Food and Drug Administration on Monday approved a Johnson & Johnson tuberculosis drug that is the first new medicine to fight the deadly infection in more than four decades.


The agency approved J&J's pill, Sirturo, for use with older drugs to fight a hard-to-treat strain of tuberculosis that has not responded to other medications. However, the agency cautioned that the drug carries risks of potentially deadly heart problems and should be prescribed carefully by doctors.


Roughly one-third of the world's population is estimated to be infected with the bacteria causing tuberculosis. The disease is rare in the U.S., but kills about 1.4 million people a year worldwide. Of those, about 150,000 succumb to the increasingly common drug-resistant forms of the disease. About 60 percent of all cases are concentrated in China, India, Russia and Eastern Europe.


Sirturo, known chemically as bedaquiline, is the first medicine specifically designed for treating multidrug-resistant tuberculosis. That's a form of the disease that cannot be treated with at least two of the four primary antibiotics used for tuberculosis.


The standard drugs used to fight the disease were developed in the 1950s and 1960s.


"The antibiotics used to treat it have been around for at least 40 years and so the bacterium has become more and more resistant to what we have," said Chrispin Kambili, global medical affairs leader for J&J's Janssen division.


The drug carries a boxed warning indicating that it can interfere with the heart's electrical activity, potentially leading to fatal heart rhythms.


"Sirturo provides much-needed treatment for patients who have don't have other therapeutic options available," said Edward Cox, director of the FDA's antibacterial drugs office. "However, because the drug also carries some significant risks, doctors should make sure they use it appropriately and only in patients who don't have other treatment options."


Nine patients taking Sirturo died in company testing compared with two patients taking a placebo. Five of the deaths in the Sirturo group seemed to be related to tuberculosis, but no explanation was apparent for the remaining four.


Despite the deaths, the FDA approved the drug under its accelerated approval program, which allows the agency to clear innovative drugs based on promising preliminary results.


Last week, the consumer advocacy group Public Citizen criticized that approach, noting the drug's outstanding safety issues.


"The fact that bedaquiline is part of a new class of drug means that an increased level of scrutiny should be required for its approval," the group states. "But the FDA had not yet answered concerns related to unexplained increases in toxicity and death in patients getting the drug."


The FDA said it approved the drug based on two mid-stage studies enrolling 440 patients taking Sirturo. Both studies were designed to measure how long it takes patients to be free of tuberculosis.


Results from the first trial showed most patients taking Sirturo plus older drugs were cured after 83 days, compared with 125 days for those taking a placebo plus older drugs. The second study showed most Sirturo patients were cured after 57 days.


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Biden, McConnell 'jump-start' stalled talks


Vice President Joe Biden looks on as President Barack Obama announces the nomination of Senator John Kerry as Secretary …Merry Cliffmas Eve?


Vice President Joe Biden and Republican Senate Minority Leader Mitch McConnell on Monday pursued behind-closed-doors efforts to avoid the “fiscal cliff” with just hours to halt painful automatic income tax hikes from biting into American paychecks.


McConnell announced on Sunday that he had reached out to Biden to help “jump-start” stalled negotiations with Democratic Senate Majority Leader Harry Reid. The two veteran Washington deal-makers spoke at 12:45 a.m. and again at 6:30 a.m., a McConnell aide said.


“The Leader and the VP continued their discussion late into the evening and will continue to work toward a solution,” McConnell spokesman Don Stewart told reporters by email on Monday, promising “more information as it becomes available.”


Senate Majority Leader Harry Reid sounded a cautious note Monday morning while noting the urgency of the situation.


“We really are running out of time,” Reid said shortly after 11 a.m. as lawmakers began a highly unusual New Year’s Eve session. “There are a number of issues on which the two sides are still apart, but negotiations are continuing as I speak.”


The two sides were wrangling over how to extend massive tax cuts adopted in 2001 and 2003 and expiring at midnight. President Barack Obama campaigned on letting tax rates rise on income above $200,000 for individuals and $250,000 for households, but any final deal is expected to set the threshold considerably higher.


“I hope we can keep in mind – and I know we will – that our single most-important goal is to protect middle class families,” said Reid. “Whether or not we reach an agreement in the short time we have left, we’ll need cooperation on both sides to prevent taxes from going up tomorrow for every family in America.”


But media reports that Biden and McConnell were closing in on a deal setting the threshold at $400,000 for individuals and $450,000 for families faced a liberal insurrection that could threaten the final compromise’s chances.


“No deal is better than a bad deal, and this looks like a very bad deal the way this is shaping up,” Democratic Senator Tom Harkin of Iowa said in the chamber.  “So we go back to the tax system that we had under Bill Clinton. I ask: What’s so bad about that?”



Lawmakers were also battling over the estate tax paid on large inheritances. Republicans have fought to extend the current levels of what they call the “death tax” – exempting estates under $5 million and taxing transfers above that at 35%.  Absent a deal, the tax will hit estates above $1 million and impose a top tax rate of 55%.


The two sides were also struggling with the so-called sequester -- $1.2 trillion in automatic cuts to domestic and defense programs over ten years. Democrats suggested Sunday that they hoped to use some of the new tax revenues to postpone some proportion of those cuts. Republicans objected, saying that only new spending cuts could be used to offset the sequester.


And there was feuding over how to spare tens of million of Americans who otherwise would find themselves paying the Alternative Minimum Tax (AMT), and over how to prevent cuts in payments to doctors who treat Medicare patients.


Any deal would need to clear both the Democratic-led Senate and the Republican-held House of Representatives. Neither looked to be an easy effort.


And it was unlikely that the compromise would spare the country another bruising partisan battle over whether and how to raise the national debt limit. Republicans have signaled that they will hold the threat of a first-ever default as leverage to win more spending cuts from the Administration. President Barack Obama has signaled that he will not negotiate on the issue the way he did in 2011, when the partisan feuding over what had typically been a routine vote in the past led to the first-ever downgrade of America’s credit rating.



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Afghan violence falls in 2012, insider attacks up


KABUL, Afghanistan (AP) — Violence in Afghanistan fell in 2012, but more Afghan troops and police who now shoulder most of the combat were killed, according to statistics compiled by The Associated Press.


At the same time, insider killings by uniformed Afghans against their foreign allies rose dramatically, eroding confidence between the two sides at a crucial turning point in the war and when NATO troops and Afghan counterparts are in more intimate contact.


"The overall situation is improving," said a NATO spokesman, U.S. Air Force Lt. Col. Lester T. Carroll. He singled out Afghan special forces as "surgically removing insurgent leaders from the battle space."


Gen. Mohammad Zahir Azimi, spokesman for the Afghan Ministry of Defense said that Afghan forces were now charged with 80 percent of security missions and were also less equipped to face the most lethal weapon of the militants — roadside bombs.


"Our forces are out there in the battlefields and combat areas more than at any other time in the past," he said, citing reasons for the spike in casualties.


U.S. troop deaths, overall NATO fatalities and Afghan civilian deaths all dropped as insurgent attacks fell off in their traditional strongholds in the country's south and east. However, insurgent activity was up in the north and west, where the Taliban and other groups have been less active than in the past, and overall levels of violence were higher than before a U.S. troop surge two years ago.


U.S. troop deaths declined overall from 404 last year to 295 deaths as of Saturday Dec. 29, as Washington draws down its forces in the country. The Defense Department says that 1,701 U.S. troops were killed in action in Afghanistan since the U.S. invasion in 2001 until Dec. 26. Of those, 338 died from non-hostile causes. Some 18,154 were wounded.


A total of 394 foreign troops including the Americans were killed in 2012, down from 543 in 2011. The British, with the second largest military presence, had 43 killed — the second highest toll among countries with forces in Afghanistan, by AP's count.


The AP keeps daily tallies of casualties and violent incidents across Afghanistan based on reports from NATO and Afghan officials. Most cannot be independently verified and other incidents may never come to light. The statistics sometimes vary from official counts because of time lags, different criteria and other reasons.


Deaths from so-called insider attacks — Afghan police and troops killing foreign allies — surged to 61 in 45 attacks last year compared to 2011, when 35 coalition troops were killed in 21 attacks.


The number, provided by the NATO command, does not include the killing of an American civilian adviser Dec. 24 by a female member of the Afghan police because the investigation is ongoing.


The focus of NATO's mission has largely veered from the battlefield to training the Afghans ahead of a pullout of most troops by 2014. The U.S plans to maintain a residual force, the size of which is now being determined.


A NATO report which tracks violence in the country, showed a rise this year compared to the period before the surge of U.S. troops into the country nearly three years ago. But the levels were down from last year and a peak in the summer of 2010. Kabul and the country's second largest city, Kandahar, saw a considerable drop in lethal attacks but districts in Kandahar province remain among the most restive in Afghanistan.


Militant attacks, the report says, decreased countrywide by 7 percent through November compared with the same 11-month period last year. But they were up in the northern and western parts of the country, which previously had been among the most peaceful regions.


Although NATO officials frequently credit Afghan troops with successful unilateral operations, a recent U.S. Congressional report noted that higher level Afghan units still need vital air, logistics and other support from foreign forces.


More Afghan police and soldiers are dying in the conflict, according to numbers provided by the interior and defense ministries.


More than 1,050 Afghan troops died this year, substantially higher than last, although the ministry could not provide the exact 2011 death toll.


Nearly 1,400 police died in the 10 months from March 21, 2012 to the end of this year, compared to about the same number for the 12 months beginning March 21, 2011. The Afghan government follows a calendar year starting March 21.


NATO says Afghan security forces have grown from 132,000 in March 2011 to 333,000 this month.


The AP tally showed that at least 822 Afghan civilians had been killed by the Taliban and other militants this year while another 119 died in NATO airstrikes and other operations. This was a decrease from last year, when 1,151 were killed by insurgents and 283 by NATO. Substantially smaller numbers perish when caught in crossfires.


The United Nations reported different casualty figures but also noted that civilian deaths had decreased, reversing a five-year trend of mounting civilian deaths. Its latest report says that during the first six months of the year, 1,145 civilians died in conflict-related violence, compared to 1,510 in the same period of 2011. The U.N. considers insurgent land mines and roadside bombs to be particularly deadly for civilians.


Close to 3,000 militants were reported to have been killed by coalition and Afghan forces this year, compared to more than 3,500 last year. The NATO command does not issue reports on the number of insurgents its troops have killed and Afghan military figures, from which the AP compiles its data, cannot be independently verified.


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